Leuprolide Acetate

The development of ovarian cysts may be avoided in two ways:

• The Lupron can be started after ovulation has occurred. Ovulation would be confirmed with a blood test and Lupron begun between the 18th and 25th day of your cycle.


• Your doctor may start you on birth control pills before introducing Lupron. You must take the Pill for at least 10 days before Lupron is started, although you may begin injecting Lupron any time after the fifth day. Once you have started Lupron, you would continue taking the Pill for five more days and then discontinue them.

Although Lupron does not appear to cause birth defects, ovulation and pregnancy that occurs with the start of Lupron therapy may be associated with a higher risk of miscarriage. For a few weeks, a newly fertilized egg depends on secretion of the hormones LH and FSH by the pituitary gland. Lupron suppresses these hormones, so the egg may have trouble developing. However, after a few weeks, the developing placenta produces enough of the hormone hCG to support the developing embryo, so after that point, Lupron would have minimal effect.

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